Later on, he also mentioned the speculation about the future of his job. "Yeah, I’m getting fired. But until then, I'm going to be there, putting out the facts for whoever's listening," he said. "And when I hear things like, 'The virus can be cured if everyone takes the Tide Pod challenge,' I'll be there to say, 'Please don't.' "

To conclude the cold open, Pitt took off his wig and glasses to thank Fauci.

"And to the real Dr. Fauci, thank you for your calm and your clarity in this unnerving time," Pitt said. "And thank you to the medical workers, first responders and their families for being on the frontline. And now live, kinda, from all across America, it's Saturday night."

Earlier this month, Fauci said he would want Pitt to portray him on SNL during a CNN interview. "Oh, Brad Pitt, of course," Fauci said when asked about which celebrity he would like to see play him.

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